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Contraindicated (one)pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these medications decrease publicity to vandetanib by approximately 40%.pentobarbital will lessen the extent or result of stiripentol by influencin